Experimental study on protective effect of breviscapine in the liver of diabetic rats
Bibliographic record
Abstract
AIM To study protective effect of breviscapine in the liver of diabetic rats. METHODS Diabetes was induced by injection of streptozotocin. Rats were randomly separated into four groups: control group, model group, model group treated with breviscapine and model group treated with vitamin E. 8 wks after STZ injection, the levels of MDA and activities of SOD, CAT as well as GSH-PX in liver tissue were determined by spectrophotometric method. Liver lesions were evaluated using HE staining. Liver fatty changes were evaluated with oil red O staining. Immunohistochemistry for ED1 (monocytes/macrophage marker) was performed by SABC technique.RESULTS Breviscapine could not prevent the decline in body weight (BW) and rise in plasma glucose (BG), Vitamin E could significantly ameliorate the decline in BW and rise in BG in diabetic rats. Light microscopy in HE staining showed that the liver from diabetic animals presented sporadic areas of hepatocytes with fatty degeneration. Breviscapine and Vitamin E group showed minor fatty degeneration in liver tissue. In the diabetic group, the presence of cytoplasmic lipid deposits was confirmed by oil red O staining. In the breviscapine group, these changes were significanly lower than those in the diabetic group. Similar results were obtained in vitamin E group. Liver tissue level of MDA in diabetic rats was higher than those of the control group, breviscapine or Vitamin E administration reduced lipid peroxidation significantly compared with the diabetic group. SOD, CAT, and GSH-PX activities were significantly reduced in the liver of the diabetic group compared with control values. Breviscapine or vitamin E administration all increased SOD, CAT and GSH-PX activities. Liver from diabetic group presented monocytes/ macrophages (ED1 positive cell) infiltration, breviscapine or vitamin E administration all reduced monocytes / macrophages infiltration. CONCLUSION The mechanism of protective effect of breviscapine may be at least partly correlated with suppression on increased oxidative stress and lipid accumulation as well as macrophage infiltration in liver in diabetic rats
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".