Effect of Recombinant Hepatical Stimulator Substance Analogue on CCl_4-induced Acute Liver Injury in Mice
Bibliographic record
Abstract
AIM:To study the effect of recombinant-shark hepatical stimulator analogue (r-sHSA) on acute liver injury induced by CCl_4 in mice.METHODS:The animal model of acute hepatitis was established by CCl_(4) (0.2%,20 mL/kg,ip),serum ALT were tested after ip administration.The changes of hepatocytes were observed through pathological section.The mechanism of r-sHSA on the liver protection was analyzed by the method of semi-quantitative RT-PCR.RESULTS:Within the concentration of 8～200 μg/kg,r-sHSA could significantly decrease the activities of rat serum ALT,and was capable of protecting liver from chemical damage.The liver protection mechanism of r-sHSA might be related with increased expression level of HGF and TNF-α and decreased expressing level of TGF-β1 as well.CONCLUSION:r-sHSA is promising to be developed as a liver protecting drug.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".