Bibliographic record
Abstract
The metabolism and elimination of florfenicol in tilapia(Oreochromis niloticus×O.caureus) following oral treatment at a dose of 12 mg/kg body mass were studied at 28 ℃ by a HPLC-MS-MS method.Results showed that the florfenicol was rapidly absorbed by tilapia 1 h after administration,and more than 1.0 μg florfenicol/mL(lethal to majority of the aquatic bacteria) was found in the tissues.There were Tmax of 5.05 h and Cmax of 6.75 μg/mL in the blood,Tmax of 6.80 h,and Cmax of 8.49 mg/kg in the muscles,and the maintenance of effective concentrations(MIC=1.0 μg/mL) beyond 50 h.The drug had longer retention time,with t1/2β of 11.18 h in blood and 12.67 h in the muscle,which AUC were 148.8 μg/(mL·h),and 225.2 mg/(kg·h).There were more rapid absorption and elimination in the blood than those in the muscle where there was higher Cmax.The fish had lower concentration of the florfenicol in the blood and muscles than the standards of U.S.FDA(1 mg/kg) and the Canadian(0.8 mg/kg) 59 h after oral administration.Therefore,florfenicol had great value for the control of diseases in fish.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".