Bibliographic record
Abstract
Aim To investigate the effect of endogenous estrogen levels on vascular endothelial function and its mechanism in women with coronary heart disease (CHD). Methods Flow mediated dilatation (FMD) of the brachial artery were detected by use of high resolution ultrasound in 33 women with CHD and 17 matched controls. Plasma estradiol were measured by radioimmulogy. Plasma concentrations of asymmetric dimethylarginine (ADMA) were measured by high performance liquid chromatopraphy. Results In comparison with control group, FMD significantly decreased in the CHD group (1.73%±1.26% vs 5.37%±3.20%, P0.001). Plasma estradiol levels were lower in the CHD group than in the controls (27.80±12.28 ng/L vs 43.83±14.30 ng/L, P0.01), whereas ADMA concentrations were higher in the CHD group than in the controls (3.39±1.07 μmol/L vs 1.31±0.69 μmol/L,P0.001). FMD was positively correlated with plasma estradiol levels (β=0.314, P0.05), but negatively correlated with ADMA (β=0.302, P0.05). Plasma estradiol levels inversely correlated with ADMA concentrations (r=-0.544, P0.001). Conclusions This study indicates that endothelium dependent vasodilatation is impaired in women with CHD. The decrease of endogenous estrogen levels accompanied with the increase of ADMA concentrations may involve in one of the mechanisms of endothelial dysfunction in women with CHD.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".