Effects of B7 Costimulatory Molecules on Th1/Th2 Cytokine Expression Levels in the Mice Infected with Schistosoma japonicum
Bibliographic record
Abstract
Objective To observe the effect of B7 1/2(CD80/CD86) costimulatory molecules on Th1/Th2 cytokine expression level in the mice infected with Schistosoma japonicum, and study the role of B7 1/2 in the shifting of Th1/Th2 immune response and granuloma formation.Methods Spleen lymphocyte cultures were prepared from the mice infected with Schistosoma japonicum at 6, 8, 10 and 12 weeks after infection. The cultures were incubated with Anti CD80 mAb and Anti CD86 mAb for 72h. The ELISA kit was used for the quantitative determination of IFN γ and IL 4 in the spleen lymphocyte culture medium.Results Anti CD80 mAb and Anti CD86 mAb could not significantly affect the IFN γ expression ( P 0 01). But they could significantly inhibit the expression of IL 4 ( P 0 01), and the effect of Anti CD86 mAb is stronger than that of Anti CD80 mAb.Conclusion The inhibition of costimulators could modulate Th1/Th2 cytokine expression level, and B7 2 molecule mainly affected Th2 type immune response. These findings suggested that B7 1/2 as a mediator of Th1/Th2 immune response could be used as a novel potential approach to control the egg granuloma formation of Schistosoma japonicum.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".