Cell and Signal Relevant Gene Expression Profile of Peripheral Blood Mononuclear Cell in Patients with Primary Sjgren's Syndrome
Bibliographic record
Abstract
Objective To explore the cell and signal relevant gene expression signatures in peripheral blood mononuclear cell(PBMC) among primary Sjgren's syndrome patients.Methods Three patients with primary Sjgren' s syndrome and 3 controls were included.The cRNA probes prepared for totle RNA were hybridized with 3 identical gene chips.The difference of cell and signal relevant gene expression were compared.Results Statistical differences were calculated between patients and controls in the following three pathways:natural killer cell mediated cytotoxicity pathway,including CD244,FASLG,CD247, GZMB,KLRD1,and ICAM1,B cell receptor signaling pathway,including CD79A,CD19,BLNK, and CD72,apoptosis pathway,including FASLG,PRKAR2B,and FADD.Among these,5 genes were upregulated and 7 genes were downregulated.Conclusion We have identified distinct cell and signal relevant gene expression profiles of PBMC from patients with primary Sjgren's syndrome and health controls,along with the research advance of gene,a new molecularbiological strategy dealing with primary Sjgren's syndrome will probably emerge.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".