Meta-analysis of bone metabolism in epileptic children receiving valproic acid
Bibliographic record
Abstract
Objective Through meta analysis to study the bone metabolism in epileptic children receiving valproic acid.Methods VIP、wanfang、CNKI、CBM、EMCC、Pubmed、OVID databases and Cochrance library were searched,included studies were all case-control studies and Review Manager 5.2 was used to analyze the data.The Newcastle Ottawa Scale(NOS) was used to evaluated the bias of included studies.Results A total of 14 case-control studies(10 in English,4 in Chinese) were included.Meta analysis showed that valproic acid had influenced bone mineral density,25-OH-VtiD,parathyroid hormone,but no influence on calcium(MD=0.01,95% CI:-0.05 to 0.06,P=0.13),phosphorus(MD=-0.03,95% CI:-0.19 to 0.13,P=0.67),alkaline phosphatase(MD=0.37,95% CI:-19.02 to 19.77,P=0.97).Bone mineral density and 25-OH-VitD levels were lower in the VPA group than in the control group(MD =-0.03,95% CI:-0.06 to-0.00,P=0.03; MD=-2.46,95% CI:-4.37 to-0.55,P=0.01,respectively).Significantly higher parathyroid hormone level was found in valporic aid group than in control group(MD=4.83,95% CI:1.15 to 8.50,P=0.01).Conclusion The study results indicated that valproic acid did affect bone metabolism in epileptic children
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.006 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.003 | 0.002 |
| Bibliometrics | 0.002 | 0.004 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".