Efficacy study on Yangxue ruanjian jiaonang in the management of osteoarthritic knee with randomized controlled trial
Bibliographic record
Abstract
Objective The purpose of this study was to investigate the efficacy of Yangxue ruanjian jiaonang (blood-nourishing and hard-softening capsules) as an adjunctive therapy relieving pain and dysfunction in elderly patients with knee osteoarthritis (OA).Methods Two hospitals participated in this clinical trial with 60 patients in each. Sixty patients with symptomatic knee OA were randomly and double-blindly assigned to treatment of blood-nourishing and hard-softening capsules,or control treatment of another traditional Chinese drug in one hospital.The other hospital designed to use western medicine (viartril-S;glucosamine) as control. A 4-week prospective two-center study with blood-nourishing and hard-softening capsules 3.15 g daily in 120 male and female outpatients with painful osteoarthritis flares of the knee was made.On the day 1, patients were all switched from their previous drugs to blood-nourishing and hard-softening capsules,followed by continuous daily treatment with blood-nourishing and hard-softening capsules in a dosage of 3.15 g daily over 4 weeks. Further endpoints included changes in selfreported pain, stiffness and functional ability as measured by the WOMAC index (Western Ontario McMaster Universities Osteoarthritis Index).Patients′ report of general health status and overall assessment of pain intensity, as measured by visual analogue scale (VAS), was related with physicians′ and patients′ assessment of the efficacy of blood-nourishing and hard-softening capsules treatment.Results Disease specific symptoms measured by the WOMAC questionnaire were significantly improved under the blood-nourishing and hard-softening capsules treatment after 4 weeks: as assessed by the WOMAC index, pain decreased by 50% and 62% (P0.001), stiffness by 54% and 67%(P0.001) and functional ability increased by 52% and 63% (P0.001) respectively in centers 1 and 2 over the course of the study.No matter using western medicine or TCM herb, there was no significant difference between the treatment and control groups.No severe adverse effects of blood-nourishing and hard-softening capsules were reported.Conclusion Blood-nourishing and hard-softening capsules, as a traditional Chinese medicine,significantly relieved pain,stiffness, and improved function, as assessed by the WOMAC questionnaire.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.005 | 0.004 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.004 | 0.002 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.007 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".