The Study of ESWAN in Vascular Cognitive Impairment-No Dementia with Small Vessel Disease
Bibliographic record
Abstract
Objective To explore the application value of Enhanced T2 Star Weighted Angiography(ESWAN) in Vascular cognitive impairment-no dementia with Small Vessel Disease(VCIND-SVD).Methods ESWAN sequence were performed on 27 VCIND-SVD patients and 11 normal comparison subjects.Meanwhile,the Montreal Cognitive Assessment(MoCA) was carried out on them by two professional neurologists.And then,the T2* and R2* value on Region of interest,included bilateral anterior cingulated gyrus,cuneate lobe,dorsalateral prefrontal cortex,posterior horn of lateral ventricle,centrum semiovale,caudate,putamen and thalamus,were being measured and the correlation between the T2* and R2* value of each ROI and each part of MoCA scores was being analyzed.Results The T2* value on ROI of bilateral anterior cingulated gyrus,dorsalateral prefrontal cortex,posterior horn of lateral ventricle,centrum semiovale and thalamus in VCIND-SVD patients was higher than that in controls(P=0.021,0.000,0.000,0.000,0.017).The R2* value was lower than that in controls(P=0.027,0.000,0.000,0.000,0.013).However,the T2* value on ROI of bilateral caudate and putamen in VCIND-SVD patients was lower than that in controls(P=0.002,0.007).The R2* value was higher than that in controls(P=0.033,0.029).Moderate correlation was showed between the score of memory item in MoCA and the T2* and R2* value on ROI of bilateral dorsalateral prefrontal cortex,posterior horn of lateral ventricle and centrum semiovale in VCIND-SVD patients(r=-0.498,-0.430,-0.453;P=0.010,0.025,0.018 and r=0.481,0.402,0.500;P = 0.013,0.037,0.008).So was that between the score of Abstraction item in MoCA and the T2* and R2* value on ROI of bilateral orsalateral prefrontal cortex(r=-0.466;P =0.017 and r=-0.447;P = 0.022).Conclusion(1) The T2* value and R2* value are able to reflect some micro-structure changes and oxygen metabolism in gray matter,white matter and deep mucleus in VCIND-SVD patients.(2)The changes of T2* value and R2* value can reflect possible pathological changes in some cognition impairment.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".