Bibliographic record
Abstract
Objective To study the immunoregulation effect of rhIL-18 on irradiated mice.Methods Thirty-two C57 mice were randomly divided into normal control group,irradiated group,rhIL-18+irradiated group,irradiated +rhIL-18 group.The animals were irradiated with 60Co (γ rays 4.0 Gy)and treated with rhIL-18 alternately.After 2 weeks,the lymphocyte transform ability,NK cells cytotoxic activity,T cells subtype were examined,the levels of IL-2,IFN-γ,GM-CSF,and IL-4 in the supernatant of cultured splenocytes in vitro and content of IgG in serum were also tested.Results rhIL-18 could make T and B lymphocyte transform function of 60Co irradiated mice to recover or even better than normal levels (P0.05).The stimulating index (SI) in irradiated +rhIL-18 group reachad to 2.9 (ConA test) and 6.1 (LPS test).rhIL-18 could enhance cytotoxic activity mediated by NK cells against tumor cells of A375,U937 and KG1 cells.The rate of killing tumor cells by NK cells was 21.8 to 35.6%(P0.05).Moreover,rhIL-18 could up-regulate the number of CD4 T cells to 50 cells/ml and improve splenocytes of irradiated mice to secret cytokines of IL-2,IFN-γ,GM-CSF(P0.05) but not IL-4 and IgG.Conclusion rhIL-18 could improve the immune function of irradiated mice.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".