Bibliographic record
Abstract
Objective To study the immunoregulation effect of rhIL-18 on irradiated mice.Methods Thirty-two C57 mice were randomly divided into normal control group,irradiated group,rhIL-18+irradiated group,irradiated +rhIL-18 group.The animals were irradiated with 60Co (γ rays 4.0 Gy)and treated with rhIL-18 alternately.After 2 weeks,the lymphocyte transform ability,NK cells cytotoxic activity,T cells subtype were examined,the levels of IL-2,IFN-γ,GM-CSF,and IL-4 in the supernatant of cultured splenocytes in vitro and content of IgG in serum were also tested.Results rhIL-18 could make T and B lymphocyte transform function of 60Co irradiated mice to recover or even better than normal levels (P0.05).The stimulating index (SI) in irradiated +rhIL-18 group reachad to 2.9 (ConA test) and 6.1 (LPS test).rhIL-18 could enhance cytotoxic activity mediated by NK cells against tumor cells of A375,U937 and KG1 cells.The rate of killing tumor cells by NK cells was 21.8 to 35.6%(P0.05).Moreover,rhIL-18 could up-regulate the number of CD4 T cells to 50 cells/ml and improve splenocytes of irradiated mice to secret cytokines of IL-2,IFN-γ,GM-CSF(P0.05) but not IL-4 and IgG.Conclusion rhIL-18 could improve the immune function of irradiated mice.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".