BCL-6,CD10 and BCL-2 protein expression in B-cell Non-Hodgkin's lymphoma and its clinicopathologic significance
Bibliographic record
Abstract
Background and Purpose:Both Bcl-6 and CD10 are markers of germinal center(GC) B cells in the lymph node.Their experssion in nodal diffuse large B cell lympoma(DLBCL),extranodal DLBCL and other types of lymphoma and the sigifcance is worthy to be investigated.This paper will investigate the protein expression of BCL-6,CD10,BCL-2 gene in B-cell Non-Hodgkin's lymphomas(B-NHL) in Chinese populations and its clinic-pathological significance.Methods:Immunohistochemical analyses of BCL-6,CD10 and BCL-2 protein expression were performed on 135 cases of B-NHL including the common types occurring in Chinese populations and 5 cases of T-NHL,5 cases of nodular lymphocyte predominance Hodgkin's lymphoma(NLPHL) and 10 cases of Reactive lymphoid hyperplasia(RLH) with paraffin-embedded tissues.Results:① BCL-6 and CD10 protein were expressed almost exclusively in RLH,nodal DLBCL,extranodal DLBCL,follicular lymphoma(FL) and Burkitt's lymphoma(BL),the rates of positivity were 100% and 100%,72.7% and 40.9%, 75.9% and 41.4%,(88.9%) and 72.2% as well as 100% and 100%,respectively.BCL-6 and CD10 protein were not expressed in other B-NHL such as small lymphocytic lymphoma(B-SLL),mantle cell lymphoma(MCL),extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue(MALT-L),Lymphoplasmacytic lymphoma(LPL) and lymphoblastic lymphoma(LBL) as well as T-NHL and NLPHL.BCL2 protein were expressed in nodal DLBCL,extranodal DLBCL,FL,B-SLL,MCL,MALT-L and LBL,the rates of positivity were 36.4%,27.6%,83.3%,(88.9%,)86.7%,72.7% and 33.3%,respectively.BCL-2 protein were not expressed in LPL,BL,T-NHL and NLPHL.② BCL-6 protein expression in DLBCL could be classified into four patterns: GC/FL pattern,intermediate pattern,sporadic pattern and rare or absent pattern.③ The coexpression of BCL-6 and CD10 was observed in 40.9% nodal DLBCL,41.4% extranodal DLBCL,72.2% FL and 100% BL.Among them the BCL-6 protein expressions were GC/FL pattern.(4)Low clinic stage(stageⅠandⅡ) was more frequent in nodal DLBCL cases with coexpression of BCL-6 and CD10 than those without(P0.05).Conclusions:Detection of BCL-6,CD10 and BCL-2 protein expression in combination may contribute to pathological diagnosis and differential diagnosis of some B-NHL.Nodal DLBCL with both BCL-6 and CD10 experssion pattern patients may have much better prognosis.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".