Effect of NG-nitro-L-argininemethyl-ester on rat myocardial injury induced by adriamycin
Bibliographic record
Abstract
Objective To study the effect of NG-nitro-L-argininemethyl-ester(L-NAME)on rat myocardial injury induced by adriamycin(ADM).Methods Eighty-five male Wistar rats were randomly divided into three groups:ADM group,ADM+L-NAME group and control group.MDA,SOD,nitric oxide(NO)and inducible nitric oxide synthase(iNOS)in myocardium and serum were detected and the pathological study was performed.Results The extent of myocardial injury in ADM+L-NAME group(16.7%)was significantly lower than that of ADM group(43.3%)with P0.05.Compared with ADM group,the contents of MDA in serium and myocardium of ADM+L-NAME group decreased significantly while the activity of SOD increased significantly.Compared with control group,the contents of nitric oxide and iNOS activity of myocardium in ADM group increased significantly.Conclusion L-NAME has protective effect on rat myocardial injury induced by ADM.The mechanism of the protective effect might related to the suppression of the iNOS activity which decreases the nitric oxide in myocardium.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".