Hypoxic hypercapnia increased blood-brain barrie's permeability and expression of AQP4 in mice
Bibliographic record
Abstract
Objective:To investigate the changes of the permeability and ultrastructure of mice’s blood-brain barrier (BBB) and expression of aquaporin-4 (AQP4) caused by hypoxic hypercapnia. Methods: The male adult C57BL/6 mice were randomly divided into six groups: the control group(C),the hypoxic hypercapnia 1d,2d, 3d,1w and 2w group. Experimental mice were exposed to normobaric hypoxic hypercapnia by placing them in a chamber. Sodium fluorescein (NaFI) was injected intraperitoneally to detect the permeability of BBB. The BBB ultrastructure was observed by electron microscope. The expression of AQP4 mRNA and protein levels were measured by Immunochemistry and PT-PCR. Results: Compared with C group, the permeability of mice's BBB increased significantly in 1 d, 2 d, 3 d and 1 w grou(pP0.05 or P0.01),which declined gradually with the prolongation of hypoxic hypercapnic exposure and had no significant increase in 2 w group. BBB ultrastructure changes were observed by electron microscope and mRNA and protein of AQP4 were upregulated significantly in 1 d group (P0.05). Conclusion: The blood-brain barrier's permeability may increase with mice's exposure to hypoxic hypercapnia at early stage, which may have the relationship to the upregulaion of AQP4.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".