National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group Report
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Abstract
The 2005 National Institutes of Health (NIH) Consensus Conference proposed new criteria for diagnosing and scoring the severity of chronic graft-versus-host disease (GVHD). The 2014 NIH consensus maintains the framework of the prior consensus with further refinement based on new evidence. Revisions have been made to address areas of controversy or confusion, such as the overlap chronic GVHD subcategory and the distinction between active disease and past tissue damage. Diagnostic criteria for involvement of mouth, eyes, genitalia, and lungs have been revised. Categories of chronic GVHD should be defined in ways that indicate prognosis, guide treatment, and define eligibility for clinical trials. Revisions have been made to focus attention on the causes of organ-specific abnormalities. Attribution of organ-specific abnormalities to chronic GVHD has been addressed. This paradigm shift provides greater specificity and more accurately measures the global burden of disease attributed to GVHD, and it will facilitate biomarker association studies.
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The record
- Venue
- Biology of Blood and Marrow Transplantation
- Topic
- Hematopoietic Stem Cell Transplantation
- Field
- Medicine
- Canadian institutions
- BC Cancer Agency
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institute of Child Health and Human DevelopmentUniversität WienNational Institute of Allergy and Infectious DiseasesNational Heart, Lung, and Blood InstituteNational Center for Advancing Translational SciencesHealth Resources and Services AdministrationIntramural Research ProgramNational Cancer InstituteNational Institutes of HealthJosé Carreras Leukämie-StiftungUniversität RegensburgAmerican Society for Blood and Marrow TransplantationPediatric Blood and Marrow Transplant ConsortiumCenter for Cancer Research
- Keywords
- MedicineDiseaseClinical trialHost (biology)Physical therapyIntensive care medicineFamily medicinePathology
- Has abstract in OpenAlex
- yes