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Record W2379936923

Comparative Analysis of the CAV-2 Fiber Protein Gene

2003· article· en· W2379936923 on OpenAlexaboutno aff
Fan Quan-shui

Bibliographic record

VenueZhongguo shouyi xuebao · 2003
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicVirus-based gene therapy research
Canadian institutionsnot available
Fundersnot available
KeywordsBiologyGeneVirulenceTropismVirologyTissue tropismPoint mutationMolecular biologyAmino acidStrain (injury)PhenotypeMutationGeneticsVirus
DOInot available

Abstract

fetched live from OpenAlex

The canine adenovirus-2(CAV-2) is associated with upper respiratory infection and intestinal syndroms.Adenovirus fiber protein(Fip) plays a crucial role in infection by attaching the virus to a specific cell-surface receptor.I n order to further explain the mechanism of difference in cell tropism and virul ence at molecular level,we designed 2 pairs of primers according to the publishe d CAV-2 Fip gene to amplify the Fip genes with PCR method.The Fip genes of the CAV-2 virulent strain SY-V5,attenuated SY-V60,SY-CP5(derived from SY-V60 pa ssed in susceptible dogs for 5 passages) and USA vaccine strain(US-V20) had bee n sequenced and compared with one another and with that of the standard CAV-2 T oronto virulent strain.Complete Fip gene of all CAV-2 strains were 1 629 nt and 542 amino acids.The deduced amino acid sequences of the Fip of the CAV-2 s trains were compared one another and with that of Toronto strain.Comparing with SY-V5 and Toronto strains,there are point mutation(transversion) occurring in S Y-V60 and SY-CP5 which changes the potential site for asparagine-linked glyco sylation.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.016
Threshold uncertainty score0.527

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.026
GPT teacher head0.314
Teacher spread0.288 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2003
Admission routes1
Has abstractyes

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