375 SINGLE DOSE ORAL DEXAMETHASONE IN THE EMERGENCY MANAGEMENT OF CHILDREN WITH EXACERBATION OF MILD TO MODERATE ASTHMA
Bibliographic record
Abstract
Objective To compare the efficacy of single dose oral dexamethasone with five days of twice daily prednisolone in the management of mild to moderate asthma exacerbation in children. Methods A prospective, randomized, double blinded trial of children 2 to 16 years of age who presented to the emergency department with acute mild to moderate asthma exacerbations. Subjects received single dose oral dexamethasone (0.6mg/kg to a maximum of 18mg) or five days of twice daily oral prednisolone (1mg/kg/dose to a maximum of 30mg). After discharge, subjects were called in 48 hours to assess progress, and re-evaluated in five days. Results Baseline characteristics were comparable in the Dex group (n=67, mean age= 60 months), and in the Pred group (n=67, mean age= 48.5months). When Dex was compared to Pred, during the first visit mean time to discharge was 210 minutes vs. 258 minutes (mean difference -48 minutes, CI: -108, 12) and admission rate was 6(9%) vs. 9(13.4%). Two subjects from the Pred group dropped out of the study due to repeated vomiting. For subjects discharged home (61 vs. 56), the admission rate after initial discharge was 3(4.9%) vs. 1(1.8%). The mean number of days needed for Patient Self Assessment score to return to baseline (0-0.5) was 5.21vs 5.22 (mean difference 0.01, CI -0.70, 0.68). Conclusion In children with mild to moderate asthma exacerbation, a single dose of oral dexamethasone (0.6 mg/kg) is safe and efficacious, when compared to five days of oral prednisolone.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".