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Record W2382944459

Effect of di-(2-ethylhexyl)-phthalate exposure on neurobehavioral and lipid peroxidation of mice

2012· article· en· W2382944459 on OpenAlex
Yang Xu

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueActa Scientiae Circumstantiae · 2012
Typearticle
Languageen
FieldNeuroscience
TopicAnesthesia and Neurotoxicity Research
Canadian institutionsL'Alliance Boviteq
Fundersnot available
KeywordsPhthalateOxidative stressLipid peroxidationSalineInternal medicineEndocrinologyBehavioural despair testPsychologyPhysiologyHippocampusMedicineChemistryAntidepressant
DOInot available

Abstract

fetched live from OpenAlex

To study the effect of DEHP on neurobehavioral(the ability of learning,memory and emotion) of Kunming mice and the oxidative damage caused by DEHP in their brain.Dividing twenty-four male kunming mice into 4 groups(n=6) randomly,including control group(Saline),low density DEHP treatment group(5 mg · kg-1 DEHP),medium density DEHP treatment group(50 mg · kg-1 DEHP) and high density DEHP treatment group(500mg/kg DEHP).To begin with,test the ability of learning and memory by Y-electric maze.Then,use the forced swimming and tail suspension tests to learn the depression of mice.Finally,the ROS level,and MDA contents of brain tissues were measured.According to the data,the ability of learning and memory of the three treatment groups are apparently lower than the control group,while their depression is extreme worse than control group(p0.05).What is more,comparing with the control group,the oxidative stress reactions of the three treatment groups are increasing significantly.The results suggest that DEHP does cause the oxidative damage in the mice's brains,which then results the abnormality of nervous behaviors.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.004
Threshold uncertainty score0.836

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.001
Scholarly communication0.0000.001
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.032
GPT teacher head0.310
Teacher spread0.278 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it