Relationship between hypoxia-inducible factor-1α,insulin-like growth factor-1,brain-derived neurotrophic factor and the cognitive function of patients with severe obstructive sleep apnea hypopnea syndrome
Bibliographic record
Abstract
Objective:To explore the change of hypoxia-inducible factor-1α,insulin-like growth factor-1,brain-derived neurotrophic factor in serum in patients with severe obstructive sleep apnea hypopnea syndrom and their relationship with cognitive function change.Method:Sixty-seven cases of patients diagnosed with OSAHS by polysomnography were defined as OSAHS group,while 17cases of healthy people as control group.Montreal cognitive assessment scale(MoCA)was employed to assess the cognitive function,and accordingly the subjects were divided into normal cognitive function group(MoCA≥26)and abnormal group(MoCA26).The level of HIF-1α,IGF-1and BDNF in serum were detected by enzyme-linked immunosorbent(ELISA).Result:Twenty cases with mild cognitive impairment(MCI)were screened in severe OSAHS group,and no case with cognitive impairment in the control group(P0.05).Compared between the control group and normal cognitive function group,significant differences were found in the level of HIF-1α(P0.05)and IGF-1(P0.01),and no significant differences were found in that of BDNF and BMI(P0.05).Compared between the control group and abnormal cognitive function group,significant differences were found in the level of HIF-1αand BDNF(P0.05),and no significant differences were found in that of IGF-1and BMI(P0.05).Compared between normal and abnormal cognitive function group,significant differences were found in the level of IGF-1(P0.01)and BDNF(P0.05),and no significant differences were found in that of HIF-1αand BMI(P0.05).In normal cognitive function group,the level of serum BDNF was positively correlated with that of IGF-1(r=0.663,P0.01)and HIF-1α(r=0.562,P0.01),respectively;and the level of IGF-1was positively correlated with that of HIF-1α(r=0.657,P0.01).However,there were no correlation between the level of BDNF,IGF-1,and HIF-1αand that of AHI,BMI and MoCA score,respectively(P0.05).In the abnormal cognitive function group,the level of serum BDNF were positively related to that of MoCA(r=0.304,P0.05),and there were no correlation between the rest factors(P0.05).Conclusion:① Compared with healthy people,the severe OSAHS patients exist mild cognitive impairment;②In patients with severe OSAHS,the level of serum HIF-1α,IGF-1and BDNF were closely correlated in the normal cognitive function group,while those were not correlated in the abnormal cognitive function group;③The serum HIF-1α,IGF-1and BDNF may jointly engage in and maintain normal cognitive function;and IGF-1,BDNF are sensitive to the changes of cognitive function.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".