Study on the relationship between Mild Cognitive Impairment and Plasma Homocysteine in middle-aged persons
Bibliographic record
Abstract
Objective To explore the relationship between mild cognitive impairment(MCI) and plasma homocysteine(Hcy) in middle-aged persons.Methods Plasma Hcy,plasma folic acid and VitB12were determined respectively in 60 MCI patients(MCI group) and 60 healthy people.32 patients with hyperhomocysteinemia(Hhcy) were treated with folic acid and VitB12for 4 weeks.The level of Plasma Hcy,Mini-Mental State Examination(MMSE) score,and Montreal Cognitive Assessment(MCOA) score were observed before and after treatment.Results Plasma Hcy in MCI group was significantly higher than that in control group(P0.05),and folic acid,VitB12,MMSE and MCOA score were lower than that in control group(P0.05).Plasma Hcy was negatively correlative with that of folic acid,VitB12,MMSE and MCOA score in MCI group(P0.05).After 4 weeks’ treatments,Plasma Hcy level in MCI group reduced compared with before treatment(P0.05),But MMSE and MCOA score was not statistically different compared with before treatment(P0.05).Conclusion Plasma Hcy level is relevant to the occurrence of mild cognitive impairment in middleaged persons,through adding folic acid and VitB12,level of plasma Hcy could be reduced,but no definite effect to cognitive function.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".