Changes of kinetic properties of hippocampal NMDA receptor in rats after severe scald burn
Bibliographic record
Abstract
Objective To investigate the changes of kinetic properties of hippocampal NMDA receptor in rat following scald burn stress. Methods Adult male Wistar rats were inflicted with 30% TBSA full thickness scalding, which was applied as severe trauma stress model. Kinetic properties of hippocampal NMDA receptor channel were detected by cell attached patch clamp technique. Results Open state probability of 35pS and 100 pS NMDA receptor channels increased markedly at 0.5 h, 1 h, 2 h, 4 h, 8 h, 24 h, and 48 h after burn. Significant change was found at 2 h. Open time of these channels also increased in some burn groups. No significant changes of NMDA receptor current amplitude and close time were found in each burn group. Conclusion Scald burn induces significant changes of kinetic properties of hippocampal NMDA receptor, resulting in hyperactivation of hippocampal NMDA receptor.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".