Preparation of Andrographis paniculata Extract Solid Dispersion by Hot-melt Extrusion Technology
Why this work is in the frame
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Bibliographic record
Abstract
OBJECTIVE:To prepare Andrographis paniculata extract solid dispersion by using hot-melt extrusion(HME)technology,and to evaluate it in vitro. METHODS:The type of hydrophilic carrier and the proprotion of A. paniculata extract to carrier were screened by single factor test using andrographolide and dehydroandrographolide as index. The preparation technology of A.paniculata extract solid dispersion was optimized. The dissolution rate in vitro was studied,and DSC,SEM,X-ray diffraction were used to analyze the solid dispersion. RESULTS:The optimal technology of A. paniculata extract solid dispersion by HME were as follows:chosing polyethylene caprolactam-polyvinyl acetate-soluplus as the carrier;the ratio of A. paniculata extract to soluplus was 1 ∶ 2(m/m);the temperate-rasing program of HME should be 130→135→140→130 ℃;the rotation rate of screw arbor was 27r/min,feeding speed was 15 g/min. The results of physicochemical characterization experiment indicated that A. paniculata extract were in amorphous state in solid dispersion by HME. CONCLUSIONS:HME can disperse A. paniculata extract in amorphous state,and improve its solubility.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it