Bibliographic record
Abstract
Objective To investigate the molecular etiology of sporadic hearing impairment by analyzing 235delC the mutation of the GJB2 in congenital deaf patients in Erdos and Hohhot,Inner Mongolia.Methods The medical histories of 131 patients with sporadic hearing impairment were collected by a questionnaire survey.The audiological examination was conducted with pure-tone audiometry and acoustic admittance measurement.GJB2 235delC mutation was identified by both PCR and restriction enzyme ApaI digestion,then the positive samples were tested with direct sequencing.50 cases of normal Chinese people and 100 cases of normal Canadian people were used for cross reference.Results 131 patients with sporadic hearing impairment were all diagnosed with sensorineural hearing impairment.4 cases had homozygous deletion C at position 235(Han 3 cases,Mongoloid 1 case)and 3 cases(Han 2 cases,Mongoloid 1 case) had heterozygous mutation in 131 patients.One carrier with the GJB2 235delC mutation was found in 50 cases of normal Chinese people,no 235delC mutation in 100 cases of normal Canadian people.Conclusions GJB2 235delC mutation is one of the molecular etiologies in sporadic patients with sensorineural hearing loss.GJB2 235delC allelic frequency between Mongoloid and Han ethnic deaf group in Inner Mongolia does not have great diversity.Screening the mutations of GJB2 235delC gene can identify pathogenesis in sporadic patients with sensorineural hearing loss,and plays an important part in early diagnosis,genetic counseling,prevention and treatment of deafness in sporadic hearing impairment caused by genetic mutation.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".