Bibliographic record
Abstract
AIM:To establish a revered-phase HPLC method for studying pharmacokinetics of loganin in serum of rat after perfusion.METHODS:The Kromasil C18(4.6 mm × 250 mm,5 μm)column was used as the analytical column and the mobile phase consisted of 0.05% phosphoric acid solution and acetonitrile,with the flow rate at 1.0 mL/min).The UV detection was set at 236 nm.RESULTS:The calibration curves of loganin was linear in the range of 26 ～ 420 ng(r = 0.999 1).The recovery and relative standard deviation of loganin was 94.20% and 4.01%,respectively.The loganin-containing serum was not changed in 24 hours(relative standard 0.55%).After a perfusion of Liuweidihuang Concentrated Pill,the mean plasma concentrations-time relationship was found to fit a one-compartment open model,the main pharmacokinetic parameters of loganin were as follows:Ka,Ke,t1/2Ka,t1/2Ke,Tpeak,Cmax,AUC were 0.008 5 /min,0.025 /min,27.95 min,81.23 min,65.59 min,6 970.40 ng/mL,1 429 620.62 ng/(mL·min).CONCLUSION:This is for the first time to establish the revered-phase HPLC method to determine concentrations of loganin in serum of Liuweidihuang Concentrated Pill and to obtain the pharmacokinetic parameters and characteristics.The method is reliable,the result is accurate.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".