Review: Some new bolus tPA-derived fibrinolytics are comparable to tPA in acute MI, but others increase bleeding
Bibliographic record
Abstract
TherapeuticsJanuary 1, 2002Review: Some new bolus tPA-derived fibrinolytics are comparable to tPA in acute MI, but others increase bleedingManu Prabhakar, MD, David Massel, MD, Manu Prabhakar, MD, David Massel, MDManu Prabhakar, MDUniversity of Western Ontario, London, Ontario, Canada (M.P., D.M., M.P., D.M.)University of Western Ontario, London, Ontario, Canada (M.P., D.M., M.P., D.M.)University of Western Ontario, London, Ontario, Canada (M.P., D.M., M.P., D.M.)Search for more papers by this author, David Massel, MDUniversity of Western Ontario, London, Ontario, Canada (M.P., D.M., M.P., D.M.)University of Western Ontario, London, Ontario, Canada (M.P., D.M., M.P., D.M.)University of Western Ontario, London, Ontario, Canada (M.P., D.M., M.P., D.M.)Search for more papers by this author, Manu Prabhakar, MDUniversity of Western Ontario, London, Ontario, Canada (M.P., D.M., M.P., D.M.)University of Western Ontario, London, Ontario, Canada (M.P., D.M., M.P., D.M.)University of Western Ontario, London, Ontario, Canada (M.P., D.M., M.P., D.M.)Search for more papers by this author, David Massel, MDUniversity of Western Ontario, London, Ontario, Canada (M.P., D.M., M.P., D.M.)University of Western Ontario, London, Ontario, Canada (M.P., D.M., M.P., D.M.)University of Western Ontario, London, Ontario, Canada (M.P., D.M., M.P., D.M.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJC-2002-136-1-006 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareFacebookTwitterLinkedInRedditEmail Source CitationLlevadot J, Giugliano RP, Antman EM. Bolus fibrinolytic therapy in acute myocardial infarction. JAMA. 2001 Jul 25;286:442-9. https://pubmed.ncbi.nlm.nih.gov/11466123Reference1 Assessment of the Safety and Efficacy of a New Thrombolytic (ASSENT-2) Investigators. Single-bolus tenecteplase compared with front-loaded alteplase in acute myocardial infarction: the ASSENT-2 double-blind randomised trial. Lancet. 1999;354:716-22. Google Scholar2 International Joint Efficacy Comparison of Thrombolytics (INJECT) Investigators. Randomised, double-blind comparison of reteplase double-bolus administration with streptokinase in acute myocardial infarction (INJECT): trial to investigate equivalence. Lancet. 1995;346:329-36. Google Scholar3 Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO III) Investigators. A comparison of reteplase with alteplase for acute myocardial infarction. N Engl J Med. 1997;337:1118-23. Google Scholar4 ASSENT-3 Investigators. Efficacy and safety of tenecteplase in combination with enoxaparin, abciximab, or unfractionated heparin: the ASSENT-3 randomised trial in acute myocardial infarction. Lancet. 2001;358:605-13. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Western Ontario, London, Ontario, Canada (M.P., D.M., M.P., D.M.)University of Western Ontario, London, Ontario, Canada (M.P., D.M., M.P., D.M.)University of Western Ontario, London, Ontario, Canada (M.P., D.M., M.P., D.M.) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails January 1, 2002Volume 136, Issue 1Page: 6KeywordsBody weightFibrinForecastingGlycoproteinsHeart failureHemorrhageHeparinInformation storage and retrievalMyocardial infarctionPercutaneous transluminal coronary angioplastyPharmacodynamicsPharmacokineticsReperfusionResearch designRevascularizationSafetySafety studiesStroke ePublished: 9 March 2020 Issue Published: January 1, 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.010 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.004 | 0.002 |
| Bibliometrics | 0.004 | 0.005 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.003 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.014 | 0.004 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".