In situ Electroporation for the Measurement of c-Ras Activation by SVLT
Bibliographic record
Abstract
Simian virus 40 large-tumor antigen (SVLT) is a largely nuclear oncogene product (1,2). Evidence from a number of laboratories has indicated that the interaction between cellular nuclear antioncogenes, such as the retinoblastomasusceptibility gene product family (Rb) and p53, mediates neoplastic transformation by SVLT, as outlined in Chapters 14 and 15. However, cytoplasmic deletion mutants, lacking the nuclear localization signal, can still transform established cell lines with efficiencies similar to that of wt SVLT. The demonstration that SVLT requires the function of the membrane-bound, cellular Ras protooncogene product to elicit neoplastic transformation of mouse or rat fibroblasts (3), provided an additional link between the nuclear cell cycle machinery and the membrane-signaling apparatus. Later work further revealed that Rb inactivation per se leads to Ras activation (4). This communication describes a novel technique to measure c-Ras activation by SVLT, as well as by other Ras stimulators.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".