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Record W2400983621 · doi:10.1017/cbo9780511545795.012

Non-genetic determinants of peak bone mass

2000· book-chapter· es· W2400983621 on OpenAlexaff
Velimir Matkovic, John D. Landoll

Bibliographic record

VenueCambridge University Press eBooks · 2000
Typebook-chapter
Languagees
FieldMedicine
TopicBone health and treatments
Canadian institutionsMcGill University
Fundersnot available
KeywordsBone massMedicineInternal medicineOsteoporosis

Abstract

fetched live from OpenAlex

Introduction Osteoporosis is becoming one of the most common chronic diseases affecting millions of people worldwide, primarily due to the aging of the world's population. Since bone fractures are closely related to diminished bone mass and reduced bone mineral density, we have to identify all underlying causes responsible for inadequate accumulation of bone tissue during skeletal growth and consolidation, and excessive losses thereafter. Maximizing bone mass during skeletal growth, therefore, has been the goal of the primary prevention of osteoporosis, while the reduction of bone loss during menopause and aging is the problem in secondary prevention programs. Until recently, the concern for patients with osteoporosis dictated a simple approach to preventive medicine, that is to reduce the number of women suffering from it. They were considered the minority, while the majority of the population without fractures was considered normal. This approach was primarily based on the X-ray diagnosis which assumed that women fall into just two categories, namely those who have the disease and those who do not (Matkovic et al., 1995b). That there is no clear distinction between the bone health and osteoporosis was originally proposed by Newton-John and Morgan (1970) and shown for the first time in a study of fracture rates among two populations with different peak bone mass (Matkovic et al., 1979).

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Other · Consensus signal: none
Teacher disagreement score0.014
Threshold uncertainty score0.046

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.000
Insufficient payload (model declined to judge)0.0140.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.020
GPT teacher head0.232
Teacher spread0.212 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations3
Published2000
Admission routes1
Has abstractyes

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Same venueCambridge University Press eBooks→Same topicBone health and treatments→French-language works237,207→