Expression, Purification, and Detection of Novel Streptococcal Superantigens
Bibliographic record
Abstract
Superantigens (SAgs) are a class of bacterial or viral proteins that aberrantly alter immune system function through simultaneous interaction with lateral surfaces of major histocompatibility (MHC) class II molecules on antigen presenting cells, and to particular variable regions of the T-cell antigen receptor (TCR) β-chain. Among the secreted virulence factors from group A streptococci are the streptococcal pyrogenic exotoxins (SPEs), also commonly known as erythrogenic toxins or scarlet fever toxins. Together with the enterotoxins and toxic shock syndrome toxin-1 (TSST-1) from Staphylococcus aureus, the SPEs belong to a larger family of related exotoxins collectively known as the “pyrogenic toxin” class of superantigens, which share functional activities, similar amino acid sequences, and conserved three-dimensional structures (1,2). Due to their notable association with scarlet fever and streptococcal toxic shock syndrome (TSS), SPE A (3,4) and SPE C (5) are generally considered to be the prototypical streptococcal superantigens.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".