Suspected Neuroleptic Catatonia Induced by Clozapine
Bibliographic record
Abstract
Objective: The neuroleptic-induced catatonia is an unusual side effect traditionally associated with high potency neuroleptics. \nMethod: We describe the case of 36-year-old woman suffering from disorganized schizophrenia, without previous history of catatonia, who developed a catatonic reaction secondary to the use of clozapine. \nResults: After having been treated with different classes of neuroleptics (i.e. haloperidol, risperidone, clotiapine, olanzapine) with alternate clinical responses, a trial of clozapine was started. Over the next two weeks, the patient’s mental conditions gradually improved but marked catatonic symptoms emerged, in the absence of any symptoms of NMS. In the hypothesis of a NIC secondary to clozapine, all medications were discontinued and lorazepam was started. Catatonic symptoms gradually improved and five days after clozapine discontinuation all symptoms disappeared. \nConclusions: This case report supports that hypothesis that atypical neuroleptics, with weak dopamine-blocking properties, such as clozapine, could also be involved in causing NIC.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.005 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.007 | 0.005 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".