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Record W2407228843 · doi:10.1097/prs.0000000000001078

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2015· letter· en· W2407228843 on OpenAlexaboutno aff
Ryan M. Gobble, Dennis P. Orgill

Bibliographic record

VenuePlastic & Reconstructive Surgery · 2015
Typeletter
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicBreast Cancer Treatment Studies
Canadian institutionsnot available
Fundersnot available
KeywordsMedicineRandomized controlled trialKetorolacPerioperativeEvidence-based medicineIntensive care medicineAlternative medicineSurgeryAnesthesia

Abstract

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Sir: We would like to thank Drs. Davidson and Turner for their comments regarding our article entitled “Ketorolac Does Not Increase Postoperative Bleeding: A Meta-Analysis of Randomized Controlled Trials.” It appears that they have published their data in the Canadian Journal of Anaesthesiology.1 Our article focused on a review of prospective, double-blind, randomized studies. As a retrospective study, although provocative, their study was not of a high enough level of evidence for us to include in our review. They do bring up the important point of understanding the risk-to-benefit issues when considering the use of drugs in the perioperative period. The question of performing elective operations on patients with either antiplatelet or anticoagulant therapies will likely become more of an issue in the future. Certainly, our report does not definitely answer the question about whether using ketorolac in breast reduction is appropriate. It simply shows where the available evidence is today and highlights where we have gaps in our knowledge. For breast reduction surgery, surgeons will have to use the available published evidence combined with their own experience and evaluation of individual patients to make this decision. Carefully performed prospective, blinded, randomized studies will ultimately need to be performed to provide more definitive guidance. DISCLOSURE The authors have no financial interest in any of the products, devices, or drugs mentioned in this communication. Ryan M. Gobble, M.D. Dennis P. Orgill, M.D., Ph.D. Brigham and Women’s Hospital Boston, Mass. [email protected]

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Commentary · Consensus signal: Commentary
Teacher disagreement score0.283
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.020
GPT teacher head0.235
Teacher spread0.215 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designNot applicable
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations3
Published2015
Admission routes1
Has abstractyes

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