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TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

2016· article· en· 824 citations· W2408084759 on OpenAlex· 10.1016/j.neuron.2016.05.003

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian funderA Canadian agency funded it. The work may carry no Canadian affiliation at all.

No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.

Abstract

No abstract. This is not a gap in this database — OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

The record

Venue
Neuron
Topic
Neuroinflammation and Neurodegeneration Mechanisms
Field
Neuroscience
Canadian institutions
Funders
National Institute of Neurological Disorders and StrokeNational Heart, Lung, and Blood InstituteUniversity of AlbertaNational Institute on AgingNational Institutes of HealthMayo ClinicU.S. Department of Veterans Affairs
Keywords
MicrogliaTREM2NeuroscienceDystrophyAmyloid (mycology)Amyloid βFunction (biology)Cell biologyBiologyMedicinePathologyImmunologyInflammationDisease
Has abstract in OpenAlex
no