Review: Donepezil improves cognitive and functional outcomes in vascular cognitive impairment
Bibliographic record
Abstract
TherapeuticsSeptember 1, 2004Review: Donepezil improves cognitive and functional outcomes in vascular cognitive impairmentSudeep S. Gill, MD, Paula A. Rochon, MDSudeep S. Gill, MDInstitute for Clinical Evaluative Sciences and Kunin-Lunenfeld Applied Research Unit, Toronto, Ontario, Canada (S.S.G., P.A.R.)Search for more papers by this author, Paula A. Rochon, MDInstitute for Clinical Evaluative Sciences and Kunin-Lunenfeld Applied Research Unit, Toronto, Ontario, Canada (S.S.G., P.A.R.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJC-2004-141-2-039 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareFacebookTwitterLinkedInRedditEmail Source CitationMalouf R, Birks J. Donepezil for vascular cognitive impairment. Cochrane Database Syst Rev. 2004;(1):CD004395. https://pubmed.ncbi.nlm.nih.gov/14974068Clinical Impact RatingsGIM/FP/GP: Geriatrics: Neurology: References1 O’Brien JT, Erkinjuntti T, Reisberg B, et al. Vascular cognitive impairment. Lancet Neurol. 2003;2:89-98. [PMID: 12849265] Google Scholar2 Snowdon DA, Greiner LH, Mortimer JA, et al. Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. JAMA. 1997;277:813-7. [PMID: 9052711] Google Scholar3 Erkinjuntti T, Kurz A, Gauthier S, et al. Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomised trial. Lancet. 2002;359:1283-90. [PMID: 11965273] Google Scholar4 Burback D, Molnar FJ, St. John P, Man-Son-Hing M. Key methodological features of randomized controlled trials of Alzheimer's disease therapy. Minimal clinically important difference, sample size and trial duration. Dement Geriatr Cogn Disord. 1999;10:534-40. [PMID: 10559571] Google Scholar5 Forette F, Seux ML, Staessen JA, et al. Prevention of dementia in randomised double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial. Lancet. 1998;352:1347-51. [PMID: 9802273] Google Scholar Author, Article, and Disclosure InformationAffiliations: Institute for Clinical Evaluative Sciences and Kunin-Lunenfeld Applied Research Unit, Toronto, Ontario, Canada (S.S.G., P.A.R.) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails September 1, 2004Volume 141, Issue 2Page: 39KeywordsActivities of daily livingAdverse eventsAlzheimer diseaseCardiovascular diseasesCaregiversCerebrovascular diseasesCholinergicsCholinesterase inhibitorsCognitionCognitive impairmentDatabasesDementiaDrugsGeriatricsInformation storage and retrievalMedical risk factorsNeurologyVascular dementia ePublished: 9 March 2020 Issue Published: September 1, 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.012 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.006 | 0.003 |
| Bibliometrics | 0.003 | 0.005 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.011 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".