Bibliographic record
Abstract
The covalent modification of cell proteins by the attachment of myristic acid, a 14 carbon saturated fatty acid, to their N-terminal amino acid is now recognized to be a widespread phenomenon (1–5). The enzyme responsible for the attachment of myristic acid to these proteins is myristoyl-CoA: Protein N-myristoyltransferase (NMT; EC 2.3.1.97). This enzyme catalyzes the transfer of myristic acid from myristoyl-CoA to the N-terminal amino acid of the target protein and results in the fatty acid being amide-bonded to the α-amino group of the amino acid. Because this transfer is susceptible to protein synthesis inhibitors, it must take place as the protein is synthesized (6,7). Data from the studies on both the sequence of known myristoylated proteins, and from those on the sequence requirements for NMT, suggests that the N-terminal amino acid is always a glycine residue (5). However the other sequence requirements for protein N-myristoylation are less certain and the resulting vague general consensus sequence is summarized in Fig. 1. Although the majority of proteins that are substrates for NMT are myristoylated, the enzyme can make use of a limited range of other fatty acids, including shorter-chain and unsaturated fatty acids. In general, this occurs when these fatty acids form the majority of the acyl-CoA pool in a cell or tissue, for example, in the retina (8). For most practical purposes, however, NMT can be regarded as essentially specific for myristic acid.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".