Routine thyroidectomy in total laryngectomy: is it really indicated?
Bibliographic record
Abstract
OBJECTIVE: To evaluate the incidence and nature of thyroid gland invasion (TGI) in laryngeal carcinoma at the head and neck centres at McGill University. METHOD: A retrospective case series was undertaken of 74 total laryngectomies performed at both McGill head and neck centres from 2001 to 2006. Thirteen specimens were excluded because thyroidectomies were not performed or laryngectomies were performed for nonprimary laryngeal carcinoma. Tumour stage, subsite, anatomic characteristics, and thyroid gland involvement were analyzed based on pathologic specimens. Pre- and postoperative radiation therapy treatment and thyroid function were also noted. RESULTS: Twenty supraglottic, 21 glottic, 15 transglottic, and 5 subglottic tumours were analyzed. Subglottic extension > 10 mm was noted in 22 specimens (36%). Cartilaginous invasion was noted in 37 of our specimens (61%), and lymph node metastasis was noted in 12 specimens (20%). One subglottic tumour demonstrated bilateral invasion of the thyroid gland and lymph node metastasis. Forty patients (54%) received preoperative radiation therapy and 34 patients (46%) received postoperative radiation therapy, with pre- and postoperative rates of hypothyroidism of 38.9% and 91%, respectively. CONCLUSION: TGI is rare for laryngeal cancer. Tumours with subglottic involvement or very advanced tumours may show a greater tendency for TGI over other tumours.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".