The Synergetic Coupling among the Cellular Antioxidants Glutathione Peroxidase/Peroxiredoxin and Other Antioxidants and its Effect on the Concentration of H2O2
Bibliographic record
Abstract
Abstract Glutathione peroxidase (GPx), peroxiredoxin (Prx) and catalase are the major antioxidants at the cellular level and protect cell compartments against hydrogen peroxide (H2O2). In addition, they affect cellular processes such as cell signaling by modulating H2O2. In this paper we demonstrate that there is a synergetic coupling between GPxs, Prxs themselves and also with other antioxidants when the GPxs and Prxs are not in their saturated reduced form. This is due to a change in the activity of glutathione peroxidases and peroxiredoxins as a result of a change in the concentrations of other antioxidants. The strength of this synergy depends on the reaction rates and the concentration of these antioxidants. We use a perturbative method to calculate the concentration of H2O2 as function of the production rate of H2O2 and the concentration of various antioxidants. This derivation shows clearly why antioxidants behave in a correlated manner and why any change in the activity of one of them translates to a change in the activity of other antioxidants. Our results show that an increase in the activity of GPxs or Prxs might not be due to a genetic switch but due to an increase in the activity of other antioxidants.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".