PTH-198 Preoperative parenteral nutrition in crohn’s disease patients requiring abdominal surgery
Bibliographic record
Abstract
Introduction The benefits of parenteral nutrition (PN) in Crohn’s Disease (CD) prior to abdominal surgery remains debatable, with two recent studies suggesting preoperative PN given to patients with moderate to severe CD minimises the risk of early postoperative complications. Method Retrospective cohort study of consecutive CD patients who received PN prior to abdominal surgery, from January 2013 to January 2015. Total days of PN received prior to surgery, changes in weight and BMI, and changes to CRP and albumin in all patients receiving PN were analysed. Adverse events related to PN, including line-related complications, and post-operative complications were also recorded. Results Of 62 operations performed for CD over the study period, 6 patients (4 male) received pre-operative PN. PN was administered via a PICC line with a dedicated lumen in all patients. All patients continued PO liquid intake and existing CD medications. 5 patients had stricturing and penetrating disease (3 with ileocaecal disease, and 2 with colonic disease). 2 of these patients had phlegmons, 2 had complex peri-anal fistulising disease, and 1 had a high output entero-cutaneous fistula. A further patient had isolated ileocolic stricturing disease. 4 patients required ileocaecal resection, 1 required panproctocolectomy and 1 sub-total colectomy. Pre-operative PN was administered for a mean of 41 days. Weight and BMI increased in all 6 patients (mean weight increased from 51.2 kg to 57.7 kg, mean BMI from 17.5 kg/m2to 19.8 kg/m2). The weight gained was maintained at routine follow-up after surgery. Mean CRP improved from 35.5 to 18.3, and albumin from 35.5 g/L to 38.3 g/L. Mean post-operative stay was 12 days, and diversion stoma was not required in 80% (4 patients). Line complications (catheter related infection/thrombosis) were not seen. One patient (16.7%) required PN withdrawal 2 days before planned surgery for suspected line sepsis not confirmed on blood cultures. No serious post-operative complications occurred, and only a single patient required antibiotics post-operatively for a small collection (not requiring surgical or radiological intervention). Conclusion In this small group of complex CD patients who received pre-operative PN, sustained weight gain and improvement in inflammatory markers was observed. Two recent studies suggest favourable postoperative outcomes, and our findings are in keeping with this. The role of optimisation with PN warrants further investigation and randomised controlled studies are required. Disclosure of interest None Declared.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".