Maternal methamphetamine use in pregnancy and long-term neurodevelopmental and behavioral deficits in children.
Bibliographic record
Abstract
AIM: To describe neurodevelopmental and/or behavioral findings among a cohort of South African children exposed to maternal methamphetamine (MA) use during pregnancy. METHODS: Developmental assessments with the Griffiths Mental Developmental Scales (GMDS) were completed on a pilot cohort of 15 toddlers aged 2-4 years with a known history of maternal MA use during pregnancy. These were compared to a matched cohort of 21 toddlers without a history of maternal MA use. Each child underwent formal auditory testing and vision screen. The Child Behavior Checklist (CBCL) was completed by a parent or caregiver. Cohorts were matched for age, gestational age at birth, socio-economic status and geographic distribution. RESULTS: Baseline characteristics were similar between the two groups. Most significant areas of poorer performance on GMDS in the Methamphetamine-exposed cohort was noted on the Personal-Social Ability Subscale (p<0.0001) and on the Hand and Eye Co-ordination Subscale (p=0.0002), while lower scores were also obtained on General Quotients (p=0.022). There were also significant concerns regarding aggressive behavior and attention deficit/hyperactivity on the CBCL for the exposed group, although this did not reach statistical significance. CONCLUSION: Among children exposed to maternal MA use during pregnancy, specific developmental and behavioral deficits were increased when compared to controls. This correlates well with available literature. Larger sample sizes would help further support these findings and more definitively distinguish behavioral deficits.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".