Efficacy of the selective treatment of clinical mastitis based on on-farm culture results
Bibliographic record
Abstract
The objective of this clinical trial was to evaluate the efficacy of using on-farm culture to guide strategic treatment decisions in cows with clinical mastitis. A total of 422 cows affected with mild or moderate clinical mastitis in 449 quarters were randomly assigned to either a) a positive-control or b) an on-farm culture-based treatment group. Quarter cases assigned to the positive-control group received immediate on-label intramammary treatment with cephapirin sodium. Quarters assigned to the culture-based treatment group were treated with cephapirin sodium if incubation of milk using an on-far culture system for 18-24 hours showed Gram-positive growth or a mixed infection. The proportion of quarters that received intramammary antibiotic therapy because of study assignment or secondary (or extended) therapy was 100% and 51% for positive-control and culture-based groups, respectively. There was a tendency for a reduction in days in which milk was discarded from cows assigned to culture-based group vs. positive-control group (5.9 vs. 5.2 days). There was no difference between cases assigned to the positive-control vs. culture-based group for days to a clinical cure (2.7 vs. 3.2 days), bacteriological cure risk (71 vs. 60%) and risk for a new intramammary infection within 21 days of enrollment (50 vs. 50%). There was no difference in the risk and days for recurrence of a clinical mastitis event in the same quarter (35% and 78 days vs. 43% and 82 days), linear somatic cell count (4.2 vs. 4.4), daily milk production (30.0 vs. 30.7 kg), and risk and days for culling or death events (28% and 160 days vs. 32% and 137 days) for the rest of the lactation. In summary, the use of on-farm culture to guide the strategic treatment of clinical mastitis reduced intramammary antibiotic use by half and tended to reduce withholding time by one day, without affecting short or long-term health or production outcomes.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".