CR-12INTRACYSTIC INTERFERON-ALPHA IN PAEDIATRIC CRANIOPHARYNGIOMA PATIENTS: AN INTERNATIONAL MULTI-CENTRE ASSESSMENT ON BEHALF OF SIOP-E AND ISPN
Bibliographic record
Abstract
BACKGROUND: Craniopharyngiomas are frequently diagnosed hypothalamo-pituitary lesions in children where they present as predominantly cystic lesions, lined by a secretory squamous epithelium. Morbidity associated with current therapeutic regimens has focussed attention towards intracystic treatments as a mode of delivery, hypothesised to cause fewer clinical consequences. However, the true efficacy of intracystic therapy remains unclear. We report the retrospective experiences of several global centres in using intracystic interferon-alpha. METHODS: All SIOP Europe and ISPN centres were contacted to submit an anonymised datasheet capturing paediatric patients in their care with a cystic craniopharyngioma that had received intracystic interferon-alpha. Patient demographics, administration schedules, adverse events and outcomes were captured. Progression was clinical or radiological (cyst re-accumulation, novel cysts, or solid growth). RESULTS: Fifty-five children (median age of 6.5 years) from over 20 international centres were identified. Median follow-up was 5 years (0.3–17.7 years; median 2.7 years post interferon). Lesions were either cystic (n = 21; 38%) or cystic/solid (n = 34; 62%). Progression had been treated in 43 (78%) patients prior to interferon use. Progression was delayed by interferon when compared to the preceding therapy for such patients (p = 0.005), especially in cystic cases (p = 0.0001). Progression post interferon occurred in 40 patients (median 14 months; 0–8 years). Few significant attributable side effects were reported. CONCLUSION: Interferon-alpha appears to delay disease progression in paediatric craniopharyngioma and has a favourable toxicity profile compared to other modalities, both important factors in this developing age group. Prospective, randomised international clinical trial assessment is warranted.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.005 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".