Preparation and Mass Spectrometric Analysis of S-Nitrosohemoglobin
Bibliographic record
Abstract
The interaction of nitric oxide NO with proteins plays a critical role in several physiological systems extending from blood pressure regulation to neu-rotransmission , , . In addition, NO produced in infected and inflamed tissue can contribute to the process of carcinogenesis , . The targets for NO on proteins are Cys and Tyr residues and bound metals such as heme-Fe2± for a recent review see ref. , through which NO exerts its effects by covalently modifying or oxidizing critical thiols or transition metals in proteins. Although much work has been performed in characterizing the NO-Fe2± interaction ,, there is considerably less data on NO-Cys interactions. One reason is the labile nature of nitrosothiols RSNOs, which are unstable in aqueous solution. It has been assumed that the lability of RSNOs is due to their propensity to undergo homolytic cleavage of the S-N bond with release of NO .
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.002 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".