AT-09TREATMENT OF ATYPICAL TERATOID RHABDOID TUMORS (ATRT) OF THE CENTRAL NERVOUS SYSTEM WITH SURGERY, INTENSIVE CHEMOTHERAPY, AND 3-D CONFORMAL RADIATION (ACNS0333). A REPORT FROM THE CHILDREN'S ONCOLOGY GROUP
Bibliographic record
Abstract
BACKGROUND: ATRT is a deadly disease that occurs primarily in young children. Prior cooperative group infant studies (POG-9923/4 and CCG-9921) demonstrated 24-month event-free survival (EFS) of < 10%. The primary objective of ACNS0333 was to determine the 6, 12, and 24 month EFS and overall survival (OS) of children with ATRT treated with intensive multimodal therapy. Secondary objectives included determining feasibility, toxicity and creation of a biologic database. METHODS: Patients, age birth to 21 years, were enrolled from 2008 to 2014. Following surgery, they received two cycles of induction chemotherapy (methotrexate, vincristine, cyclophosphamide, etoposide, and cisplatin). Patients without tumor progression received three cycles of high-dose thiotepa and carboplatin with autologous stem cell rescue and involved field radiation therapy. The order of the consolidation and radiation was dependent on patient age as well as extent and location of disease. SMARCB1 alterations were confirmed in all tumors. RESULTS: For the entire 65 patient cohort, 24-month EFS and OS were 42% and 53%. For 54 patients < 3 years of age, the 24 month EFS and OS were 39% and 48%. These are significant improvements compared to historical control studies above (p < 0.025). Failures were unusual after 2 years. There were two treatment-related deaths during therapy. CONCLUSIONS: Intensive, multimodality therapy on ACNS0333 resulted in improved EFS and OS compared to prior cooperative group studies. Although the therapy was tolerable, further intensification is not feasible. Molecular subtyping of ATRT may help stratify patients and identify targeted therapies to improve treatment outcomes even more.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".