HG-57RE-IRRADIATION IN PATIENTS WITH DIFFUSE INTRINSIC PONTINE GLIOMAS, AN UPDATE ON THE CANADIAN EXPERIENCE
Bibliographic record
Abstract
OBJECTIVE: More than 90% of the children diagnosed with DIPG will succumb within two-years of diagnosis. Clinical-trials have failed to demonstrate a survival benefit of adjuvant chemotherapy. Radiotherapy is the only effective treatment thus far but of limited duration. The aim of this study is to determine the safety and efficacy of re-irradiation. METHOD: We retrospectively reviewed demographic, clinical and radiation data of all patients with DIPG treated in Canada with re-irradiation. RESULTS: Since January 2011, 13 patients with progressive DIPG received re-irradiation. Median age at diagnosis was 5 years. Median time from diagnosis to progression was 12 months (range,4-37m). Re-irradiation total dose varied between institutions from 21.6Gy to 36Gy. Re-radiation was given focally in 85% of the patients. Re-irradiation was well tolerated by all children. Four patients had transient tiredness and decrease of appetite during treatment. One patient suffered pontine necrosis with brainstem dysfunction with 30Gy in 10 fractions. All but two showed neurological improvement. With a median follow-up from diagnosis of 19.8 months, all patients died, with a median time from re-irradiation to death of 6 months (range,5-13m). When compared to an historic cohort of 46 patients, median time from progression to death was 92 days in the non re-irradiated patients, vs. 173 days in the re-irradiated ones (p < 0.05). CONCLUSION: In this limited experience re-irradiation was safe and feasible in patients with progressive DIPG, providing neurological recovery and a prolonged life span. A prospective Canadian re-irradiation protocol is in progress to evaluate treatment benefit including quality of life.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".