Novel Associations of F2-Isoprostanes, F3- Isoprostanes and Isofurans in Older Adults with Chronic Fatigue Syndrome: An Exploratory Study
Bibliographic record
Abstract
Plasma levels of F 2 -isoprostanes (F 2 -IsoPs), a whole body oxidative stress marker, have been noted to be elevated in populations with chronic fatigue syndrome (CFS).We hypothesized that the oxidative stress biomarkers of F 2 -isoprostanes (F 2 -IsoPs), isofurans (IsoFs) and F 3 -isoprostanes (F 3 -IsoPs) are related to hypothalamic-pituitary-adrenal (HPA) axis dysregulation in chronic fatigue syndrome (CFS) subjects assessed by plasma dehydroepiandrosterone (DHEA) and cortisol and gene expression of sirtulin-1 (SIRT1).Plasma samples were obtained from nine CFS individuals aged 65 years or older.The mean levels of plasma F 2 -IsoPs (M=178 pg/ml, SD=100) and IsoFs (M=266 pg/ml, SD=205) were several-fold higher than previously reported in healthy subjects.F 2 -IsoPs:F 3 -IsoPs and SIRT1 were negatively associated (r=-.674,p<.05) whereas F 3 -IsoPs were inversely correlated with DHEA (r=-.586,p<.05) and positively associated with SIRT1 (r=.733, p<.05).After correction for age and sex, the F 2 -IsoPs:IsoFs ratio was positively correlated to DHEA:cortisol (r=.758, p<.05).The findings indicate that plasma IsoFs and F 2 -IsoPs are elevated in older subjects with CFS and that isoprostane and isofuran ratios are associated with HPA dysregulation.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".