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Record W2463011059 · doi:10.1093/joneph/20.2.119

Surrogate end points in clinical trials: the case of anti-neutrophil cytoplasm antibody-associated vasculitis

2007· article· en· W2463011059 on OpenAlexaff
Michael Walsh, Marcello Tonelli, David Jayne, Braden Manns

Bibliographic record

VenueJournal of Nephrology · 2007
Typearticle
Languageen
FieldMedicine
TopicVasculitis and related conditions
Canadian institutionsInstitute of Health EconomicsUniversity of AlbertaUniversity of Calgary
Fundersnot available
KeywordsMedicineVasculitisSurrogate endpointAnti-neutrophil cytoplasmic antibodyAntibodyImmunologyANCA-Associated VasculitisNeutrophil extracellular trapsCytoplasmClinical trialInternal medicineInflammation

Abstract

fetched live from OpenAlex

Michael Walsh, Marcello Tonelli, David Jayne, Braden Manns; Surrogate end points in clinical trials: the case of anti-neutrophil cytoplasm antibody-associa

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.527
metaresearch head score (Gemma)0.646
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesMetaresearch
DomainCandidate signal: Methods · Consensus signal: Methods
Study designCandidate signal: Theoretical or conceptual · Consensus signal: none
GenreCandidate signal: Methods · Consensus signal: none
Teacher disagreement score0.473
Threshold uncertainty score0.583

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.5270.646
Meta-epidemiology (narrow)0.0030.002
Meta-epidemiology (broad)0.0160.006
Bibliometrics0.0030.006
Science and technology studies0.0020.010
Scholarly communication0.0090.013
Open science0.0040.007
Research integrity0.0170.037
Insufficient payload (model declined to judge)0.0030.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.054
GPT teacher head0.400
Teacher spread0.347 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; the direct Gemma label and the distilled Codex classifier agree on what is shown here.

Study designTheoretical or conceptual
DomainMethods
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations4
Published2007
Admission routes1
Has abstractyes

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