P1‐182: Pattern of aberrant brain activity in patients with mild cognitive impairment and lacunar infarction: A resting‐state functional MRI study
Bibliographic record
Abstract
Lacunar infarctions (LI) have been associated with a cognitive decline and an increased risk of dementia. However, the specific pattern of spontaneous brain activity in patients with mild cognitive impairment (MCI) and concomintant silent lacunar infarction, remains unclear. Our objective was to assess the differences in spontaneous brain activity in MCI patients with silent LI versus those without LI using resting-state functional magnetic resonance imaging (rs-fMRI). We recruited consecutive patients from dementia clinic in Nanjing, China, who met Petersen's criteria for amnestic MCI. For comparison, we included cognitively normal subjects (CN). All underwent structural and rs-fMR imaging at 3T. Presence of LI in basal ganglia, thalami, capsulae and deep white matter was ascertained using fluid attenuation inversion recovery images and University of Edinburgh Neuroimaging Stroke Scale by two independent raters blinded to diagnoses. In total, 22 MCI patients with LI (MCI-LI), 26 MCI patients without LI (MCI-no LI) and 28 CN without LI were included. Functional volumes were post-processed using regional homogeneity (ReHo) and the amplitude of low-frequency fluctuation (ALFF) methods. Differences in ALFF and ReHo values were assessed using analysis of covariance. Between group voxel-wise comparisons using t-test were conducted, controlling for age, sex, years of education and modulated grey matter maps obtained from T1 segmentation. Differences were considered significant when p<0.05, AlphaSim corrected. ALFF and ReHo were correlated with global cognitive scores. Compared with CN, the MCI-LI patients had lower ReHo and ALFF in precuneus/cuneus (PCC), insula and medial frontal gyrus (MFG). Compared to MCI-no LI, MCI-LI patients had lower ALFF in superior-medial frontal gyrus (SFG), MFG, anterior cingulate cortex (ACC) and lower ReHo in PCC and insula. Conversely, MCI-no LI patients had greater ReHo and ALFF in the hippocampi and parahippocampal gyri, SFG, MFG, ACC, and greater ALFF in left caudate. Montreal Cognitive Assessment score correlated with ALFF in MFG (r=0.43, p=0.045) in MCI-LI patients.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".