Canakinumab for Childhood Sight-threatening Refractory Uveitis: A Case Series
Bibliographic record
Abstract
To the Editor: Pediatric noninfectious uveitis embraces a group of inflammatory eye diseases responsible for severe ocular complications and blindness. Therapeutic options encompass topical or systemic steroid therapy, conventional immune-modulatory therapy, and tumor necrosis factor-α (TNF-α) antagonists1. The use of anti-TNF-α modifier immunosuppressant treatment may apply to refractory cases2. Canakinumab is a human monoclonal antibody (IgG1) directed against interleukin 1β. It has been successfully used in cryopyrin-associated periodic syndromes3, systemic-onset juvenile idiopathic arthritis (JIA)4, refractory Behçet disease5,6, and colchicine-resistant familial Mediterranean fever7. Preliminary evidences suggest the efficacy of canakinumab for refractory eye diseases in patients affected by Blau syndrome8, juvenile Behçet syndrome9, and chronic infantile neurologic cutaneous and articular syndrome10. Here we report 2 children affected by refractory sight-threatening uveitis who have been successfully treated … Address correspondence to Dr. A. Brambilla, AOU Anna Meyer Children’s Hospital, viale Pieraccini 24, Florence, Italy. E-mail: alice.brambilla02{at}ateneopv.it
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.005 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.002 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.003 | 0.002 |
| Scholarly communication | 0.002 | 0.003 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.009 | 0.005 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".