Prevalence of Celiac Disease in Children With Type 1 Diabetes Mellitus in Southeast Region of Turkey
Bibliographic record
Abstract
Background: Although the relationship between celiac disease (CD) and type 1 diabetes mellitus (DM) is well recognized, there are no studies of this association in Southeast Region of our country. The aim of this study was to identify the prevalence of CD in a group of children with type 1 DM undergoing treatment in the Pediatric Endocrinology Department of our hospital. Methods: The patients followed up with diagnosis of type 1 DM in the Outpatient Clinics of Pediatric Endocrinology in our hospital were enrolled in the study. Anti-tissue transglutaminase (anti-tTG) IgA was measured in blood collected from these patients. Patients with anti-tTG IgA positive then had duodenal biopsy. Biopsy samples were obtained through an endoscopy procedure. Biopsy specimens were evaluated and classified according to Marsh classification. Results: The study participants consisted of 218 patients (girls, n = 117: 53.7%; boys, n = 101: 46.3%) with type 1 DM with a mean age of 12.9 ± 4.5 years (range 2 - 18 years). Sixteen patients had anti-tTG IgA positive. All of the cases with positive serology underwent duodenal biopsy. On histopathological evaluation, 11 patients had mucosal alterations compatible with celiac disease; five patients had non-specific histologic changes or normal biopsies. The prevalence of CD was 5% among 218 patients. Five cases with normal biopsy results were evaluated as having latent CD. Conclusions: These findings indicate that the prevalence of CD in children with type 1 DM was higher than that in general population. Periodic screening of diabetic children and adolescents in terms of CD is indicated to ensure early diagnosis and treatment. Int J Clin Pediatr. 2016;5(2):32-35 doi: http://dx.doi.org/10.14740/ijcp239w
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".