Does An 8-week Lower Body Exercise Program Improve Quality Of Life In Teenagers With Dysautonomia?
Bibliographic record
Abstract
PURPOSE: Dysautonomia, including syncope, affects at least 1% of teenagers and is associated with significant impairments in quality of life (QoL). The therapeutic options for physicians managing these patients are typically limited to increasing fluid and salt intake, as well as physical counter pressure maneuvers. In this pilot study, we sought to determine whether adolescents with dysautonomia improve their QoL following a prescribed body weight resistance training program. METHODS: Patients with dysautonomia were invited to participate and underwent cardiac assessment including an exercise test. QoL questionnaires (Peds QL) were completed by participants and their parents prior to starting the home-based exercise program. Exercises consisted of: squats, squat holds, lunges, planks, hip bridges, and step-ups. Participants were asked to perform 3 sets of 15 repetitions, 5 days per week. Isometric exercise duration was increased progressively. Participants were asked to keep a diary of symptoms and their exercise sessions. Contact with families was made over the course of the program to improve compliance. After 8-weeks, participants returned for a repeat exercise test and QoL questionnaires. RESULTS: We enrolled 11 participants, 7 of whom completed the study protocol. Two were excluded due to other medical issues; one did not complete the exercise program, and one was lost to follow-up. The mean age was 15.1 yrs (13.1-15.5). Height: 164 (157-181)cm; Weight: 59.0 (51.6-68.0)kg. All participants completed the exercises at least 3 days per week, up to the prescribed 5 days per week. QoL scores were significantly higher in the participants post intervention [41.67 (32.61-80.43) vs 72.21 (40.22-95.65); p=0.027]. Parent proxy reports for the QoL of their teens also improved [45.0 (28.26-79.34) vs 73.8 (41.3-100.0); p=0.046]. Cohen’s d=0.85 suggests a large clinically relevant effect size. There was no significant change in treadmill time [600 seconds (300-779) vs 591 (480-840); p=0.138]. CONCLUSION: This is the first study to demonstrate that an 8-week body weight resistance training program is feasible and can improve QoL in adolescents with dysautonomia.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".