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Record W2468034639 · doi:10.1021/jacs.5b10993

Exclusive Csp<sup>3</sup>–Csp<sup>3</sup> vs Csp<sup>2</sup>–Csp<sup>3</sup> Reductive Elimination from Pt<sup>IV</sup> Governed by Ligand Constraints

2015· article· en· W2468034639 on OpenAlexafffund
Eric G. Bowes, Shrinwantu Pal, Jennifer A. Love

Bibliographic record

VenueJournal of the American Chemical Society · 2015
Typearticle
Languageen
FieldChemistry
TopicAsymmetric Hydrogenation and Catalysis
Canadian institutionsUniversity of British Columbia
FundersAmerican Chemical Society Petroleum Research FundCanada Foundation for InnovationNatural Sciences and Engineering Research Council of CanadaUniversity of British ColumbiaGovernment of Canada
KeywordsChemistryLigand (biochemistry)Reactivity (psychology)BromideReductive eliminationThermal decompositionMedicinal chemistryRadiochemistryOrganic chemistryCatalysis

Abstract

fetched live from OpenAlex

Selective reductive elimination of ethane (Csp(3)-Csp(3) RE) was observed following bromide abstraction and subsequent thermolysis of a Pt(IV) complex bearing both Csp(3)- and Csp(2)-hybridized hydrocarbyl ligands. Through a comparative experimental and theoretical study with two other Pt(IV) complexes featuring greater conformational flexibility of the ligand scaffold, we show that the rigidity of a meridionally coordinating ligand raises the barrier for Csp(2)-Csp(3) RE, resulting in unprecedented reactivity.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.004
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Science and technology studies, Research integrity, Insufficient payload (model declined to judge)
Consensus categoriesMeta-epidemiology (narrow), Research integrity
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.488
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0020.004
Meta-epidemiology (narrow)0.0020.002
Meta-epidemiology (broad)0.0040.004
Bibliometrics0.0000.004
Science and technology studies0.0010.004
Scholarly communication0.0010.002
Open science0.0040.002
Research integrity0.0020.005
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.012
GPT teacher head0.246
Teacher spread0.234 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; both teacher heads agree on what is shown here.

Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations34
Published2015
Admission routes2
Has abstractyes

Explore more

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