Effect of Salba‐Chia ( <i>Salvia Hispanica</i> L), an Ancient Seed, in the Treatment of Overweight and Obese Patients with Type 2 Diabetes: A Double‐blind, Parallel, Randomized Controlled Trial
Bibliographic record
Abstract
Preliminary studies indicate that consumption of Salba‐chia ( Salvia hispanica L) improves management of type 2 diabetes and acutely suppresses appetite. In this study, we assessed the effect of Salba‐chia on body weight and related cardiovascular disease risk factors in overweight or obese adults with type 2 diabetes over 6 months. Using a double blind, parallel, controlled trial design, 77 overweight or obese patients with type 2 diabetes (HbA1c 6.8–8.5%; BMI 25–40kg/m 2 ) were recruited. Both groups followed a 6‐month calorie‐restricted diet; one group consumed 30g/1000kcal of Salba‐chia, the other 36g/1000kcal oat bran‐based control, per day. Primary endpoint was change in body weight over 6‐months. Secondary endpoints included changes in waist circumference, body fat %, HbA1c, blood pressure, lipids, C‐reactive protein, and obesity‐related gut hormones. Fifty four participants completed the full 6‐month protocol and 58 (31 Control, 27 Salba‐Chia) were included in the final analysis. At 6‐months, participants on Salba‐chia lost significantly more weight than those on oat bran‐based control (1.9±0.5kg and 0.3±0.4kg, respectively; p= 0.020), accompanied by a greater reduction in waist circumference (3.5±0.7cm and 1.1±0.7cm, respectively; p= 0.027). C‐reactive protein was reduced by 1.1±0.5mg/L (39±17%) on Salba‐chia, compared to 0.2±0.4mg/L (7±20%) on control ( P= 0.045) and plasma adiponectin was increased on Salba‐chia by 6.5±0.7% compared to 0.0±0.6% on control ( P= 0.022). There were no significant differences between treatments on blood pressure, lipids and HbA1c, and fat distribution, however, a within intervention reduction of android (3.7±2.8%, P =0.031) and gynoid fat (6.9±3.9%, P =0.047) was observed in the Salba‐chia group, but not in control. The current trial demonstrates the potential of Salba‐chia to promote weight loss, and improve obesity‐related risk factors, while maintaining good glycemic control. The results suggest Salba‐chia may represent a promising supplementation to conventional therapy in the treatment of overweight and obesity in diabetes. Support or Funding Information Canadian Diabetes Association Operating Grant, Salba‐chia was provided by Salba Smart Natural Products, LLC
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".