HPLC determination of sildenafil and its demethylated metabolite, UK-103,320, in cat plasma with solid-phase extraction for the pharmacokinetic study
Bibliographic record
Abstract
Une methode d'analyse simple et fiable par chromatographie liquide a haute performance fut developpee pour la determination simultanee du sildenafil et de son metabolite demethyle (UK-103,320) dans le plasma de chat. Une extraction en phase solide avec une cartouche de SepPak C 1 8 fut utilisee apres deproteinisation, et les taux de recuperation de l'extraction furent de plus de 85% pour le sildenafil et UK-103,320. Le coefficient de variation etait de moins de 15% dans le domaine 50-1000 ng/ml pour les sildenafil et UK-103,320, ce qui indique une reproductibilite acceptable pour la methode. Cette methode fut employee pour une etude pharmacocinetique apres l'administration orale de citrate de sildenafil. Une analyse de moment a revele que la demi-vie d'elimination (7.4 ′ 2.1 hr) etait similaire a celles rapportees dans des etudes avec du [ 1 4 C]-sildenafil, et le pourcentage AUC du UK-103,320 sur le sildenafil etait aussi semblable aux resultats d'un rapport precedent. Ces resultats indiquent que cette methode analytique commode est promptement applicable aux etudes pharmaco-cinetiques de sildenafil et UK-103,320.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".